46.  Micromorphology Characteristics of Hybrid Materials Type Layered Double Hydroxides - Antibiotics Studied by SEM Analysis

Authors: G. Carja, S. Ratoi, G. Ciobanu, S. Dranca, G. Lehutu


Abstract:

Hydrotalcite is a cheap, human health friendly material that belongs to the class of anionic clays. The lamellar matrices of anionic clays are formed by positively charged layers, counterbalanced by exchangeable interlayer anions; their high adsorption and high anionic exchange capacities allow using them as biocompatible matrices for designing drug clay formulations. For the process of the drug delivery the micromorphology features of the hybrid drug-clay formulations are very important. We present here new results regarding the textural features of the hydrotalcite-like anionic clay incorporated with cefotaxime and chloramphenicol. Scanning electron microscopy (SEM) was used like technique to analyze the micromorphology characteristics of the antibiotic-clay hybrid formulations. The studied samples were obtained by using direct coprecipitation method or the calcination reconstruction method; their structural features were studied by using XRD analysis. The inorganic matrix and the organic drug both contribute to establish the specific micromorphology characteristics of the materials. The typical platelet morphology of the clay is destroyed and new features, defined by well tailored microsheets stacked one of top of the others, appear.


Keywords: anionic clays, hybrids, antibiotics, scanning electron microscopy (SEM)

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